A cordon has been put in place in Darnall following the discovery of a suspicious item at a residential address on Uttley Close.
Following advice from the army's Explosive Ordinance Disposal team, approximately 40 houses within the 100m cordon will be evacuated as a precautionary measure while further examination takes place.
Arrests have been made in relation to this matter and two women from Sheffield remain in police custody for questioning.
Chief Superintendent Stuart Barton said: "The suspicious item was found during a search of a property and we are following standard procedures to ensure the safety of the nearby residents and officers at the scene.
"We apologise for any inconvenience this may cause to local residents, these precautionary measures are in place to ensure safety, and we will be in continual contact with those affected until they are able to return to their homes.
"I would ask people not to approach the cordon, to allow clear access for the specialists to complete their work."
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